Table 2.
Observed and expected numbers of unique R and S mutations per time point and overall in the large clone of Sjögren’s syndrome subject 2
| Time | N | CDR R obs | CDR S obs | FWR R obs | FWR S obs | CDR R exp | CDR S exp | FWR R exp | FWR S exp |
|---|---|---|---|---|---|---|---|---|---|
| All |
55 |
6 |
24 |
46 |
47 |
27.18 |
9.59 |
62.36 |
23.86 |
| Week 0 |
1 |
1 |
1 |
6 |
9 |
3.76 |
1.33 |
8.59 |
3.32 |
| Week 8 |
17 |
5 |
18 |
30 |
36 |
19.67 |
6.94 |
45.12 |
17.27 |
| Week 14 |
7 |
1 |
11 |
17 |
22 |
11.27 |
3.98 |
25.86 |
9.89 |
| Week 26 |
10 |
1 |
14 |
22 |
25 |
13.70 |
4.84 |
31.43 |
12.03 |
| Week 36 |
6 |
2 |
5 |
18 |
22 |
10.39 |
3.67 |
23.83 |
9.12 |
| Week 52 | 14 | 1 | 5 | 10 | 22 | 8.40 | 2.96 | 19.27 | 7.37 |
Shown are the observed (obs) and expected (exp) numbers of replacement (R) and silent (S) mutations within each unique clonally related variant at each time point for members of the big clone in Sjögren’s syndrome subject 2. Both the complementarity-determining region (CDR) and the framework region (FWR) exhibit significant negative selection at all time points and overall (P <0.05 by the focused selection test; see Methods). N, number.