Figure 5.

Genome-wide survival analysis stratified by ER status. This smoothed scatterplot shows the distribution of the prognostic association of 13,091 genes in ER+ (X-axis) and ER- (Y-axis) breast cancer. The P-values plotted have been corrected for multiple hypothesis testing using the method of Benjamini and Hochberg [25]. The color represents the density of genes and ranges from white > beige > gray > black > orange > red, with red the most dense and white the most sparse. The dotted black lines represent a significance threshold of adjusted P = 0.05. The blue triangle represents PGR and the green triangle represents ESR1. PGR expression is associated with prognosis in ER+ breast cancer; however, 727 genes are more prognostic than PR with the most prognostic genes showing a prognostic association to the significance level of P <1 × 10¹² as compared with the prognostic significance level of 3 × 10^–4 achieved by PR.