Table 1.
AβDP | Cytosol | Nucleus | Mitochondria | Peroxisomes | Endosomes | Lysosomes | ER/Golgi | Extracellular |
---|---|---|---|---|---|---|---|---|
Plasmin |
|
|
|
|
|
|
- |
✚ |
NEP |
|
|
|
|
|
|
✚ |
✚ |
ECE1 |
|
|
|
|
✚ |
(+) |
- |
- |
ECE2 |
|
|
|
|
✚ |
✚ |
|
|
IDE |
✚ |
✚ |
✚ |
✚ |
- |
|
|
✚ |
PreP |
|
|
✚ |
|
|
|
|
|
CatB |
|
|
|
|
✚ |
✚ |
✚ |
✚ |
CatD | - | (+) | ✚ | - | - |
Plus sign indicates present and proteolytically active, and minus sign indicates present but not active (inactivity is due to pH or other factors); (+) indicates mixed evidence for activity. AβDP, amyloid β-protein-degrading protease; CatB, cathepsin B; CatD, cathepsin D; ECE, endothelin-converting enzyme; ER, endoplasmic reticulum; IDE, insulin-degrading enzyme; NEP, neprilysin; PreP, presequence protease.