Table 1.
Examples of amyloid β-protein-degrading proteases with distinct localization profiles
| AβDP | Cytosol | Nucleus | Mitochondria | Peroxisomes | Endosomes | Lysosomes | ER/Golgi | Extracellular |
|---|---|---|---|---|---|---|---|---|
| Plasmin |
|
|
|
|
|
|
- |
✚ |
| NEP |
|
|
|
|
|
|
✚ |
✚ |
| ECE1 |
|
|
|
|
✚ |
(+) |
- |
- |
| ECE2 |
|
|
|
|
✚ |
✚ |
|
|
| IDE |
✚ |
✚ |
✚ |
✚ |
- |
|
|
✚ |
| PreP |
|
|
✚ |
|
|
|
|
|
| CatB |
|
|
|
|
✚ |
✚ |
✚ |
✚ |
| CatD | - | (+) | ✚ | - | - |
Plus sign indicates present and proteolytically active, and minus sign indicates present but not active (inactivity is due to pH or other factors); (+) indicates mixed evidence for activity. AβDP, amyloid β-protein-degrading protease; CatB, cathepsin B; CatD, cathepsin D; ECE, endothelin-converting enzyme; ER, endoplasmic reticulum; IDE, insulin-degrading enzyme; NEP, neprilysin; PreP, presequence protease.