Table 4.
Comparison of cytokine profile in SF according to ACPA status (number = 51)
| SF cytokines |
Total |
ACPA positive |
ACPA negative |
P value |
|---|---|---|---|---|
| Number = 51 | Number = 40 | Number = 11 | ||
| GM-CSF (pg/ml) |
0 (0 to 0) |
0 (0 to 0) |
0 (0 to 0) |
0.461 |
| IFNγ (pg/ml) |
0 (0 to 0) |
0 (0 to 0) |
0 (0 to 0) |
0.828 |
| IL-1β (pg/ml) |
0 (0 to 7.9) |
2.61 (0 to 12.2) |
0 (0 to 0) |
0.011 |
| IL-2 (pg/ml) |
0 (0 to 159.3) |
38.9 (0 to 164) |
0 (0 to 0) |
0.076 |
| IL-4 (pg/ml) |
0 (0 to 0) |
0 (0 to 0) |
0 (0 to 0) |
0.280 |
| IL-5 (pg/ml) |
0 (0 to 0) |
0 (0 to 0) |
0 (0 to 0) |
0.714 |
| IL-6 (pg/ml) |
1,252.6 (4.3 to 47.4) |
1,260.8 (774.9 to 1,725.1) |
1,170.6 (628.8 to 1,568.4) |
0.697 |
| IL-10 (pg/ml) |
16.2 (4.3 to 47.4) |
26.7 (6.9 to 57.1) |
0 (0 to 13.4) |
0.001 |
| IL-12p70 (pg/ml) |
0 (0 to 0) |
0 (0 to 0) |
0 (0 to 0) |
0.682 |
| IL-13 (pg/ml) |
0 (0 to 0) |
0 (0 to 0) |
0 (0 to 0) |
0.688 |
| IL-17 (pg/ml) |
0 (0 to 26.2) |
0 (0 to 33.2) |
0 (0 to 0) |
0.160 |
| IL-17 F (pg/ml) |
142.7 (0 to 532.6) |
269.9 (23.1 to 534.8) |
9.2 (0 to 71.2) |
0.021 |
| IL-21 (pg/ml) |
783 (0 to 1,162.4) |
820.8 (0 to 1,158.3) |
0 (0 to 1,381.4) |
0.493 |
| IL-22 (pg/ml) |
0 (0 to 0) |
0 (0 to 91.8) |
0 (0 to 0) |
0.207 |
| IL-23 (pg/ml) |
259 (0 to 863.1) |
311.7 (0 to 1,028.4) |
169.4 (0 to 472.3) |
0.372 |
| CCL20 (pg/ml) |
445.5 (59.0 to 3,521.1) |
1,437.9 (179.3 to 3,928.0) |
39.2 (5.6 to 161.9) |
<0.0001 |
| TGF-β1 (pg/ml) |
768 (0 to 1,927.7) |
924.4 (0 to 1,918.3) |
0 (0 to 2,035.3) |
0.277 |
| TNFα (pg/ml) |
0 (0 to 16.3) |
0 (0 to 16.2) |
0 (0 to 17.6) |
0.636 |
| TNFβ (pg/ml) | 0 (0 to 13.1) | 0 (0 to 13) | 0 (0 to 15.2) | 0.759 |
Data are expressed as median (IQR). CCL20: CC chemokine ligand 20, GM-CSF: Granulyte macrophage-colony stimulating factor, TGF: Transforming growth factor, TNF: Tumor necrosis factor.