Table 2.
Comparison of clinical manifestations in childhood-onset SLE and adult-onset SLE
| Clinical manifestations | Odds ratio | 95% confidence interval | I2 (%)a |
|---|---|---|---|
| More common in childhood-onset SLE | |||
| Fever | 1.48 | 1.24 to 1.76 | 0 |
| Thrombocytopenia | 1.30 | 1.10 to 1.55 | 0 |
| Ulcers/mucocutaneous | 1.35 | 1.13 to 1.61 | 0 |
| Urinary cellular casts | 2.35 | 1.68 to 3.29 | 0 |
| Seizures | 2.32 | 1.65 to 3.25 | 16 |
| Hemolytic anemia | 1.90 | 1.44 to 2.52 | 17 |
| Combined IgG and IgM aCL | 1.66 | 1.20 to 2.28 | 41 |
| More common in adult-onset SLE | |||
| Sicca | 0.42 | 0.27 to 0.64 | 0 |
| Pleuritis | 0.69 | 0.54 to 0.88 | 0 |
| Rheumatoid factor | 0.53 | 0.32 to 0.87 | 0 |
aCL, anti-cardiolipin antibody; SLE, systemic lupus erythematosus. aI2 statistic was used to examine the between-study heterogeneity. Only disease features with I2 <50% were included in the table.