Table 1.

Structures of selected compounds tested for sGC activity

Compound	R1	R2	cGMP production (pmol/ng protein)	Percent occupancy of sGCcat
2	—	—	22.70 ± 3.15	85
4	H		14.35 ± 0.11	90
5	H		3.22 ± 0.15	101
6	H		2.33 ± 0.15	21
7	H		9.09 ± 0.31	34
8	H		4.05 ± 0.33	20
9			2.23 ± 0.06	62
10			15.56 ± 1.3	40
11	H		2.08 ± 0.01	94
12	H		9.11 ± 0.07	96
13	H		2.72 ± 0.22	28
DMSO control			2.21 ± 0.15