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. 2014 Mar 13;156(6):1247–1258. doi: 10.1016/j.cell.2014.01.049

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© 2014 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Figure S5 — Three Possible Models for the Evolutionary History of Kinetochores, Related to Figure 5

(A) The LECA (last eukaryotic common ancestor) had conventional kinetochores. In this scenario, kinetoplastids lost conventional kinetochores and evolved KKT-based kinetochores after they branched from other eukaryotic lineages.

(B) The LECA had KKT-based kinetochores. In this scenario, only kinetoplastids retained them.

(C) The LECA had a hitherto unknown type of kinetochores.

Note that this is a highly simplified set of possibilities of how the diversity of kinetochore types may have arisen in evolution. The diagrams are presented as simple branch points and do not incorporate multiple other branch points leading to the diversity of other eukaryotic groups.