Table 3.
Genes differentially expressed by cartilage calcification in samples from six patients with osteoarthritis
| Gene name | Gene ID | Differential gene expression (fold-change) compared with OA cartilage without calcification | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CPP crystals | CA crystals | CPP + CA | |||||||
| OA1 | OA2 | OA3 | Mean | OA4 | OA5 | Mean | OA6 | ||
| ENPP1 (PC-1) | MIM 173335 | 2.98 | 2.29 | 2.59 | 2.62** | 2.54 | 1.09 | 1.81 (NS) | 2.5 |
| ANKH | MIM 605145 | 3.54 | 2.67 | 4.94 | 3.72* | 2.66 | 1.83 | 2.24 (NS) | 1.82 |
| TNAP | MIM 171760 | 2.20 | 7.74 | 56.10 | 22.01 (NS) | 9.26 | 2.20 | 5.73 (NS) | 2.17 |
| SLC20A1 (Pit1) | MIM 137570 | 1.55 | 1.34 | 0.82 | 1.24 (NS) | 1.82 | 1.63 | 1.72 (NS) | 1.19 |
| NT5E (CD73) | MIM 129190 | 0.82 | 1.27 | 0.78 | 0.96 (NS) | 2.00 | 0.57 | 1.28 (NS) | 1.59 |
ANKH, ankylosis progressive homolog; CA, carbonated apatite; CPP, calcium pyrophosphate; ENPP1, ectonucleotide pyrophosphatase 1; NS, not significant; NT5E, 5'-nucleotidase (ecto) or CD73 protein; OA, osteoarthritis; SLC20A1, solute carrier family 20 (phosphate transporter), member 1 or Pit1; TNAP, tissue nonspecific alkaline phosphatase. **P < 0.01 (vs. samples without calcification), *P < 0.05 (vs. samples without calcification).