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. 2013 Nov 27;5(6):51. doi: 10.1186/alzrt225

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Copyright © 2013 Meister et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Influence of free or nanoparticulate flurbiprofen on Aβ generation in an in vitro BBB model. 7WD10 cells were co-cultured abluminal with post-confluent bEnd.3 cells in the luminal compartment (A). bEnd.3 cells were treated with the indicated concentrations of free flurbiprofen (B) or PLA-flurbiprofen nanoparticles (C) for 72 hours. Levels of Aβ in the abluminal compartments were measured by an Aβ specific ELISA. The data represent mean ± SEM of three independent experiments. * Statistically significant difference (P <0.05, two-way ANOVA) between Aβ levels of vehicle-treated and drug-treated cells are indicated. Aβ, amyloid-β; ANOVA, analysis of variance; BBB, blood-brain barrier; PLA, polylactide; SEM, standard error of the mean.