Table 3.
Odds ratios and 95% confidence intervals for polymorphisms with statistically significant associations with risk of breast cancer.
| Genes and SNPs | Frequency of genotypesa | OR (95% CI)b Pc | FPRPd BFDPe | |
|---|---|---|---|---|
| BMAL1 | No. of cases | No. of controls | ||
| rs2278749 | ||||
| CC | 375 | 381 | 1.0 | |
| CT | 141 | 164 | 0.93 (0.70- 1.22) | |
| TT | 13 | 30 | 0.45 (0.23- 0.90) 0.02 | 0.16 0.21 |
| Ptrend = 0.07 | ||||
| CLOCK | ||||
| rs3749474 | ||||
| CC | 223 | 228 | 1.0 | |
| CT | 251 | 260 | 1.01 (0.78- 1.31) | |
| TT | 68 | 108 | 0.64 (0.45- 0.92) 0.02 | 0.14 0.11 |
| Ptrend = 0.03 | ||||
| AANAT | ||||
| rs3760138 | ||||
| TT | 149 | 181 | 1.0 | |
| TG | 269 | 315 | 1.00 (0.75- 1.32) | |
| GG | 128 | 106 | 1.42 (1.01- 2.01) 0.05 | 0.13 0.18 |
| Ptrend = 0.07 | ||||
| rs4238989 | ||||
| GG | 161 | 203 | 1.0 | |
| GC | 263 | 288 | 1.13 (0.86- 1.49) | |
| CC | 120 | 104 | 1.43 (1.01- 2.01) 0.04 | 0.11 0.16 |
| Ptrend = 0.13 | ||||
aNumber of cases and controls with successful genotyping data. bOdds ratios (ORs) derived from unconditional logistic regression and adjusted for age at diagnosis (cases) or day of reference (controls), selection period, alcohol use, hormone replacement therapy for the past 2 years, number of children and history of breast cancer in first-degree family (mother or sister). cPearson's χ2 test (two-sided) comparing frequency of the homozygote variant genotypes with homozygote common genotypes (reference). dThe false-positive report probability (FPRP) was calculated as described by Wacholder et al. [42]. FPRP < 0.2 was considered noteworthy. eThe Bayesian false-discovery probability (BFDP) was calculated as described by Wakefield et al. [41]. BFDP < 0.8 was considered noteworthy. For more details on FPRP and BFDP, see Methods section. Ptrend values for the Cochran-Armitage trend test were calculated from 2×C tables using frequency of cases and controls.