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. 2013 Dec 5;15(6):R208. doi: 10.1186/ar4401

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Copyright © 2013 Wang et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Anti-CypA single-domain antibody A1 suppresses matrix metalloproteinase-9 and human inflammatory cytokine production in SCID-HuRAg mice. (A) Representative images of matrix metalloproteinase (MMP)-9 staining of each treatment group under a microscope (n = 6 per group) (magnification × 400). (B) Statistical results for the expression of MMP-9 in each treatment group. (C) The blood of sacrificed mice was obtained and the levels of cytokines were detected by cytometric bead array (CBA). Results are expressed as the mean ± standard error of the mean with n = 6 per group. *P <0.05 compared with the control antibody group, **P <0.01 versus control antibody group. IHC, immunohistochemistry; IL, interleukin; PBS, phosphate-buffered saline; sdAb, single-domain antibody; TNF, tumor necrosis factor.