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. 2014 Apr 4;6(2):e00141. doi: 10.1042/AN20140004

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© 2014 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

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(a) Potentiation by sevoflurane (SEVO, 1%) of inward (upper panel) and outward currents (lower panel) elicited by focal muscimol application (10 μM, 10 ms; ▲) in neocortical neurons at P5 and adult stage, respectively. (b) Degree of the sevoflurane (1%) potentiation of muscimol (10 μM, 10 ms)-elicited current (I_muscimol) in neocortical neurons at different developmental stages. NS: statistically insignificant. (c) Action potential triggering in a neocortical neuron at P5 by depolarizing GABAergic PSP potentiated by sevoflurane (SEVO, 1%). The bottom trace show the case where the potentiated PSP succeeded to evoke an action potential, whereas the middle one illustrates the occasion when the potentiated PSP failed to evoke spike. The depolarizing GABAergic PSP was evoked by electrical stimulation (↑) of a site near the recorded cell, in the presence of AP-5 (100 μM), DNQX (20 μM) and CGP 54626 hydrochloride (1 μM) in the slice-perfusing medium.