Table 3.
wGRS results of antimicrotubule agents, docetaxel, and paclitaxel-induced alopecia
|
Cat |
Score |
G2
a
|
G1
b
|
G0
c
|
%-G2 |
%-G1 |
%-G0 |
G2 vs. G0 |
G1 vs. G0 |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR d* | 95%CI | P value | OR d* | 95%CI | P value | ||||||||
|
Antimicrotubule (6 SNPs) |
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
<5.56 |
2 |
7 |
34 |
0.05 |
0.16 |
0.79 |
|
Ref |
|
|
Ref |
|
| 2 |
5.56-7.60 |
25 |
20 |
50 |
0.26 |
0.21 |
0.53 |
8.50 |
1.89-38.3 |
1.66E-03 |
1.94 |
0.74-1.42 |
2.52E-01 |
| 3 |
7.60-9.63 |
65 |
17 |
19 |
0.64 |
0.17 |
0.19 |
58.2 |
12.8-265 |
4.93E-14 |
4.35 |
1.53-12.4 |
6.42E-03 |
| 4 |
>9.63 |
26 |
6 |
1 |
0.79 |
0.18 |
0.03 |
442 |
38.0-5140 |
2.71E-14 |
29.1 |
3.02-282 |
8.39E-04 |
| |
Total |
118 |
50 |
104 |
|
|
|
|
|
|
|
|
|
|
Docetaxel (4 SNPs) |
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
<2.26 |
1 |
5 |
23 |
0.03 |
0.17 |
0.79 |
|
Ref |
|
|
Ref |
|
| 2 |
2.26-4.70 |
9 |
6 |
14 |
0.31 |
0.21 |
0.48 |
14.8 |
1.69-130 |
4.39E-03 |
1.97 |
0.51-7.68 |
4.88E-01 |
| 3 |
4.70-7.15 |
33 |
5 |
4 |
0.79 |
0.12 |
0.10 |
190 |
19.9-1810 |
1.01E-11 |
5.75 |
1.12-29.4 |
4.08E-02 |
| 4 |
>7.15 |
19 |
2 |
0 |
0.90 |
0.10 |
0.00 |
611 |
23.5-15900 |
2.50E-11 |
21.4 |
0.89-511 |
4.83E-02 |
| |
Total |
62 |
18 |
41 |
|
|
|
|
|
|
|
|
|
|
Paclitaxel (7 SNPs) |
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
<3.24 |
2 |
4 |
28 |
0.06 |
0.12 |
0.82 |
|
Ref |
|
|
Ref |
|
| 2 |
3.24-7.48 |
4 |
14 |
22 |
0.10 |
0.35 |
0.55 |
2.55 |
0.43-15.2 |
4.01E-01 |
4.46 |
1.28-1.92 |
2.60E-02 |
| 3 |
7.48-11.7 |
35 |
12 |
11 |
0.60 |
0.21 |
0.19 |
44.6 |
9.12-218 |
9.55E-10 |
7.64 |
2.02-28.9 |
2.30E-03 |
| 4 |
>11.7 |
16 |
5 |
0 |
0.76 |
0.24 |
0.00 |
376 |
17.0-8320 |
1.54E-10 |
69.7 |
3.26-1490 |
2.89E-04 |
| Total | 57 | 35 | 61 | ||||||||||
aIndividuals who developed grade 2 alopecia; bindividuals who developed grade 1 alopecia; cindividuals who did not developed any ADRs after chemotherapy; dORs and CIs are calculated using category (group) 1 as reference. *OR calculated after Haldane’s correction: adding 0.5 to all the cells of a contingency table if any of the cell expectations would cause a division by zero error. Cat, category; OR, odds ratio; CI, confidence interval; Ref, reference.