Figure 4.

Average native sequence recovery for CDR H3 loops in germline antibodies and their corresponding mature forms. The single-constrain design strategy was used in all cases. Note that for this analysis we grouped as germline the antibody state with no or short-term exposure to antigen (which was omitted in all simulations) and as mature the corresponding antibody after longer term exposure to the same antigen. In each case, a corresponding pair consists of structures that are both either bound to the same epitope or free (Table III). The star indicates that the observed difference is statistically significant (as determined by a Binomial test).