Table I.
Dataset of germline and mature antibody structures
| Antibody Name |
Structures (PDB code) |
Resolution (Å) |
CDR H3 loop RMSD (Å) |
CDR H3 loop No. of residues |
||
|---|---|---|---|---|---|---|
| Bound | Free | Bound | Free | |||
| 7g12 | 1n7m | 1ngz | 1.8 | 1.6 | 1.0 | 5 |
| 28b4 | 1fl6 | 1fl5 | 2.8 | 2.1 | 1.8 | 8 |
| az-28 | 1dv6 | 1d5i | 2.0 | 2.0 | 1.2 | 11 |
| 36–65 | 2a6i | 2a6j | 2.5 | 2.7 | 0.6 | 12 |
| s25-2 | 1q9q | 1q9k | 1.5 | 2.0 | 2.2 | 11 |
| 48g7 | 1a7j | 2rcs | 2.1 | 2.1 | 0.8 | 5 |
| pc282 | 1kcs | 1kcv | 2.5 | 1.8 | 1.6 | 6 |
| 3f4 | 1cu4 | 1cr9 | 2.9 | 2.0 | 1.0 | 5 |
| 50-1 | 1ggi | 1ggc | 2.8 | 2.8 | 1.7 | 5 |
| nc6-8 | 2cgr | 1cgs | 2.2 | 2.6 | 0.8 | 7 |
| bv04 | 1cbv | 1nbv | 2.7 | 2.0 | 1.1 | 10 |
| 17-9 | 1ifh | 1hil | 2.8 | 2.0 | 2.0 | 11 |
| spe7 | 1oau | 1oaq | 1.8 | 1.5 | 1.5 | 11 |
| mn12h2 | 1mpa | 1mnu | 2.6 | 2.5 | 0.8 | 12 |
The CDR H3 loop of these antibodies shows conformational changes in bound and free conformations according to X-ray data.
Antibodies are classified as germline (rows 1 to 6) and mature (rows 7 to 14) according to published data.