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In vitro replication of EphA2-TEA-VV in CV-1 cells and normal human cells. The replication of EphA2-TEA-VV, GFP-VV, and vSC20 in (a) CV-1, (b) A549 tumor cells, and (c) normal human fibroblast are shown. Cells were infected at a multiplicity of infection of 0.1, and after 1, 2, or 3 days, viral titers were determined using plaque assays in CV-1 cells. EphA2-TEA-VV, EphA2-T-cell engager-armed vaccinia virus; pfu, plaque-forming units.
