Figure 3.

Increased survival in hCPCeβct overexpressing β₁-adrenergic receptor in response to catecholamine stimulation. (a) Increased survival in hCPCeβct compared with hCPCe overexpressing β₁-adrenergic receptor and in the presence of isoproterenol as evidenced by FACS based cell death analysis (n = 3). No change after isoproterenol induced cell death in metoprolol treated hCPCeβct and hCPCe. (b) Enhanced cAMP activity in hCPCe overexpressing β1-adrenergic receptor stimulated with isoproterenol at 2 and 6 hours compared with hCPCeβct as measured by cAMP assay (n = 3). hCPCe + β1-AR vs. hCPCeβct + β1-AR *P < 0.05, **P < 0.01, ***P < 0.001. hCPC, human cardiac progenitor cell.