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. 2013 Oct 29;22(1):42–51. doi: 10.1038/mt.2013.218

Figure 2.

Figure 2

Vector tropism and in vivo transgene product expression. (a) Graphs show the levels of AAV vector genome 24 hours after intravenous transfer in liver, lungs and spleen of mice injected with an AAV8 vector with wild-type capsid (closed bars) or a SIINFEKL-modified capsid (open bars). Differences between the two vectors were not statistically significant by t test. (b) Graphs show average levels of h.FIX ± SD in groups of five male BALB/c mice on day 14 following intravenous injections with AAV8 vectors with wild-type (left) or SIINFEKL-modified (right) capsid. Differences between the groups were not statistically significant (Mann–Whitney test).