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The physical and chemical properties of CD98 siRNA/PEI–loaded polylactic acid (PLA) nanoparticles (NPs). (a) Schematic structure of PLA NPs loaded with CD98 siRNA/PEI. (b) Scanning electronic microscopy of CD98 siRNA/PEI–loaded NPs (500 μg/ml in suspension). (c) Atomic force microscopy of CD98 siRNA/PEI–loaded NPs (500 μg/ml in suspension, scale bar is 1 µm). (d) Size distribution and zeta potential (mV) measured by light-scattering analysis.
