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. 2013 Nov 26;22(1):69–80. doi: 10.1038/mt.2013.214

Figure 6.

Figure 6

Daily gavage with CD98 siRNA/polyethyleneimine (PEI)–loaded polylactic acid (PLA) nanoparticles (NPs) reduces inflammation in dextran sodium sulfate (DSS)-treated mice. (1 and 2) H&E staining of colon sections from mice treated with (a) water, (b) 3% DSS + empty NPs, and (c) 3% DSS + CD98 siRNA/PEI NPs. (3) Colonoscopies of mice treated with (a) water, (b) 3% DSS + empty NPs, and (c) 3% DSS + CD98 siRNA/PEI NPs. Scale bar = 50 µm. (4) Histologic and (5) endoscopic score of severity of inflammatory infiltrate, extent of crypt damage and ulceration used to generate a total histological and endoscopic score.

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