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. 2013 Dec 17;22(1):123–131. doi: 10.1038/mt.2013.238

Figure 1.

Figure 1

Herpes simplex virus (HSV)-1 and HSV-2 ICP0 mutants show differences in cytopathic effect, cellular metabolism and viral burst size in vitro. Bright field and green fluorescent protein fluorescence images of TUBO cells infected with (a) HSV-1 or (b) HSV-2 ICP0 mutants for 24 hours. Cellular metabolism of TUBO cells 24 hours following infection with HSV-1 or HSV-2 ICP0 mutants at (c) MOI 1 and (d) MOI 5. Burst sizes of HSV-1 and HSV-2 ICP0 mutants in TUBO cells 48 hours following infection with an (e) MOI of 0.5. The average and standard deviations are from three independent experiments each run with three biological replicates. The statistical significance of the mean differences between groups was analyzed using ANOVA. ***P < 0.0005, **P < 0.005.