Figure 5.

Locally administered HSV-1 dICP0 is rapidly cleared from subcutaneous tumors. Replication of HSV dICP0 mutants in subcutaneous tumors of TUBO cells in BALB/c mice. (a) Log of total flux calculated following IVIS imaging of tumor-bearing mice treated with firefly luciferase expressing oncolytic HSV dICP0 viruses. Luciferase activity was measured following injection of mice with D-luciferin (n = 5 for each treatment). (b) Viral titers from tumors that were resected and homogenized at the indicated times posttreatment.