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. 2013 Dec 19;73(1):2–13. doi: 10.1097/NEN.0000000000000020

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Copyright © 2013 by the American Association of Neuropathologists, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.

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Clinical course, motor performance, and survival in mice with early meningitis. Comparisons of clinical presentation, extent of weight loss, and motor performance assessed by tightrope test and Rotarod treadmill during bacterial meningitis between Faim2^+/+ and Faim2^−/− mice. The decrease in motor performance (tightrope test p < 0.01, accelerod p < 0.05) and the extent of weight loss (p < 0.001) 24 hours after infection were significant and are typical features of the acute phase of meningitis but did not differ significantly between the genotypes. Spontaneous survival time after meningitis in Faim2^+/+ and Faim2^−/− mice without antibiotic treatment was recorded in hours and evaluated by Kaplan-Meier plot illustrating no significant difference in survival between the 2 genotypes during early meningitis (p = 0.313). ns, not significant.