Table 2.

Summary of effects of platelet-rich plasma on mesenchymal stem cells from various tissue sources in vitro

Cell type	Intervention	Outcome	Reference
Sheep BMSCs	Double-spun PRP activated by CaCl2	Increased cell proliferation and Col II mRNA expression	[34]
Human BMSCs	50% platelet lysate after two cycles of freezing and thawing	Promoted proliferation and triggered chondrogenic differentiation	[55]
Human BMSCs	10% inactivated PRP (leukocyte concentration unreported)	Enhanced cell proliferation and Sox9, aggrecan and RUNX2 mRNA expression	[56]
Rabbit BMSCs, ADSCs	10% double-spun inactivated PRP	Increased cell proliferation and expression of Sox9, aggrecan, Col II and Col I mRNA and proteins	[21]
Mouse MDSCs	Double-spun PRP	Promoted cell proliferation, adhesion and migration of MDSCs, and increased number of cells producing Col II and cell apoptosis	[58]
Human subchondral progenitor cells	5% P-PRP after freezing and thawing	Increased cell migration and cartilaginous matrix formation, but did not affect osteogenic and adipogenic differentiation	[60]

ADSC, adipose-derived mesenchymal stem cell; BMSC, bone marrow-derived mesenchymal stem cell; Col, collagen; MDSC, muscle-derived mesenchymal stem cell; P-PRP, pure platelet-rich plasma; PRP, platelet-rich plasma.