Table 4.
Correlation of carotid and femoral artery intima-media thickness with traditional and nontraditional risk factors for atherosclerosis a
| Variable |
SSc (n = 90) |
SLE (n = 100) |
||||||
|---|---|---|---|---|---|---|---|---|
|
Mean CCA IMT |
Mean CFA IMT |
Mean CCA IMT |
Mean CFA IMT |
|||||
| Correlation | P value | Correlation | P value | Correlation | P value | Correlation | P value | |
| Age (years) |
r = 0.682 |
<0.001 |
r = 0.565 |
<0.001 |
r = 0.726 |
<0.001 |
r = 0.560 |
<0.001 |
| Age at diagnosis (years) |
r = 0.652 |
<0.001 |
r = 0.586 |
<0.001 |
r = 0.670 |
<0.001 |
r = 0.437 |
<0.001 |
| Disease duration (months) |
r = -0.030 |
0.782 |
r = -0.109 |
0.308 |
r = 0.094 |
0.357 |
r = 0.217 |
0.032 |
| Male sex |
rφ = 0.261 |
0.013 |
rφ =0.341 |
0.001 |
rφ = 0.268 |
0.007 |
rφ = 0.208 |
0.039 |
| Postmenopausal status |
r = 0.546 |
0.001 |
r = 0.375 |
0.001 |
r = 0.400 |
<0.001 |
r = 0.373 |
<0.001 |
| Body mass index |
r = 0.128 |
0.241 |
r = 0.197 |
0.070 |
r = 0.258 |
0.012 |
r = 0.294 |
0.004 |
| Systolic blood pressure (mmHg) |
r = 0.303 |
0.007 |
r = 0.332 |
0.003 |
r = 0.346 |
0.001 |
r = 0.171 |
0.124 |
| Glomerular filtration rate |
r = -0.316 |
0.003 |
r = -0.489 |
<0.001 |
r = -0.296 |
0.003 |
r = -0.277 |
0.006 |
| Nicotine pack-years |
r = 0.022 |
0.839 |
r = 0.320 |
0.002 |
r = 0.082 |
0.424 |
r = -0.058 |
0.570 |
| Coronary heart disease |
rφ = 0.160 |
0.133 |
rφ = 0.379 |
<0.001 |
rφ = 0.265 |
0.008 |
rφ = 0.160 |
0.115 |
| mRSS |
r = 0.225 |
0.036 |
r = -0.021 |
0.843 |
– |
– |
– |
– |
| SCL70 antibody |
rφ = -0.117 |
0.270 |
rφ = -0.209 |
0.048 |
– |
– |
– |
– |
| Centromere antibody |
rφ = 0.165 |
0.119 |
rφ = 0.255 |
0.015 |
– |
– |
– |
– |
| SLEDAI |
– |
– |
– |
– |
r = -0.166 |
0.115 |
r = -0.057 |
0.591 |
| SLICC |
– |
– |
– |
– |
r = 0.208 |
0.049 |
r = 0.117 |
0.271 |
| dsDNA antibody |
– |
– |
– |
– |
rφ = -0.188 |
0.063 |
rφ = -0.197 |
0.051 |
| Nucleosomes antibody | – | – | – | – | rφ = -0.231 | 0.021 | rφ = -0.123 | 0.224 |
CCA, common carotid artery; CFA, common femoral artery; dsDNA, double-stranded DNA; IMT, intima-media thickness; mRSS, modified Rodnan Skin Score; SLE, systemic lupus erythematosus; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; SLICC, Systemic Lupus International Collaborating Clinics damage index; SSc, systemic sclerosis.
aOnly variables suggested for multivariate linear regression analysis are reported; complete report available in Additional file 1.