Table 4.
One-locus analysis of the non–human leukocyte antigen genes included in this study a
| SNPs | Location | BD patients | Controls | P | OR (95% CI) |
|---|---|---|---|---|---|
|
LOC100129342 |
|
|
|
|
|
| rs11206377 |
Chr1:39821691 |
|
|
|
|
| A |
|
280 (0.48) |
279 (0.45) |
|
|
| G |
|
306 (0.52) |
347 (0.55) |
>0.05 |
|
|
IL23R |
|
|
|
|
|
| rs17375018 |
Chr1: 67427735 |
|
|
|
|
| A |
|
149 (0.26) |
197 (0.32) |
|
|
| G |
|
431 (0.74) |
415 (0.68) |
0.01 |
1.37 (1.06-1.78) |
| rs7517847 |
Chr1:67454257 |
|
|
|
|
| G |
|
189 (0.33) |
272 (0.43) |
|
|
| T |
|
391 (0.67) |
354 (0.57) |
0.0001 |
1.59 (1.25-2.02) |
| rs1343151 |
Chr1:67491717 |
|
|
|
|
| A |
|
192 (0.33) |
250 (0.40) |
|
|
| G |
|
390 (0.67) |
374 (0.60) |
0.01 |
1.36 (1.07-1.73) |
|
IL10 |
|
|
|
|
|
| rs3024498 |
Chr1: 205008152 |
|
|
|
|
| C |
|
89 (0.15) |
115 (0.18) |
|
|
| T |
|
495 (0.85) |
507 (0.82) |
>0.05 |
|
| rs2222202 |
Chr1:205012004 |
|
|
|
|
| A |
|
200 (0.34) |
254 (0.41) |
|
|
| G |
|
388 (0.66) |
366 (0.59) |
0.01 |
1.35 (1.06-1.71) |
| rs1800872 |
Chr1:205013030 |
|
|
|
|
| A |
|
172 (0.30) |
157 (0.25) |
|
|
| C |
|
408 (0.70) |
463 (0.75) |
>0.05 |
|
|
CPVL |
|
|
|
|
|
| rs317711 |
Chr7:29068833 |
|
|
|
|
| C |
|
143 (0.25) |
164 (0.27) |
|
|
| G |
|
429 (0.75) |
454 (0.73) |
>0.05 |
|
|
TDRD7 |
|
|
|
|
|
| rs2061634 |
Chr9:99145603 |
|
|
|
|
| C |
|
453 (0.79) |
468 (0.75) |
|
|
| G |
|
123 (0.21) |
154 (0.25) |
>0.05 |
|
|
UBASH3B |
|
|
|
|
|
| rs4936742 |
Chr11:12214629 |
|
|
|
|
| C |
|
302 (0.54) |
327 (0.53) |
|
|
| T |
|
258 (0.46) |
291 (0.47) |
>0.05 |
|
|
UBAC2 |
|
|
|
|
|
| rs7999348 |
Chr13:98730923 |
|
|
|
|
| A |
|
407 (0.71) |
430 (0.70) |
|
|
| G | 169 (0.29) | 182 (0.30) | >0.05 |
aBD, Behçet’s disease; CI, confidence interval; OR, odds ratio; Pc, conditional probability; SNP, single-nucleotide polymorphism. An allelic model was used. Allelic frequencies are the number of each specific allele divided by the total number of alleles (number of individuals × 2) are shown within the parentheses.