Table 2.
Inverse-variance weighted analysis of allelic associations
| |
|
|
|
European Caucasian and low ancestry Polynesian
d
|
High ancestry Polynesian
e
|
Polynesian
f
|
All ancestries
g
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chr:Pos b | Effect/Other c |
OR
h
|
P h | Het P h |
OR
h
|
P h | Het P h |
OR
h
|
P h | Het P h |
OR
h
|
P h | Het P h | |
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | ||||||||||||
| 1a |
rs475414 |
11:64241844 |
T/C |
1.02 |
0.862 |
0.990 |
1.15 |
0.233 |
0.727 |
1.12 |
0.270 |
0.839 |
1.07 |
0.376 |
0.861 |
| (0.85,1.22) |
(0.92,1.43) |
(0.92,1.34) |
(0.93,1.23) |
||||||||||||
| 1 |
rs17299124 |
11:64256859 |
C/A |
0.94 |
0.539 |
0.425 |
3.38 |
6.1 × 10,4 |
0.674 |
1.95 |
0.006 |
0.153 |
1.71 |
0.109 |
0.010 |
| (0.76,1.16) |
(1.69,6.79) |
(1.21,3.15) |
(0.89,3.28) |
||||||||||||
| 2 |
rs693591 |
11:64325069 |
C/G |
0.99 |
0.942 |
0.559 |
1.25 |
0.051 |
0.053 |
1.23 |
0.047 |
0.113 |
1.12 |
0.167 |
0.087 |
| (0.78,1.26) |
(1.00,1.57) |
(1.00,1.51) |
(0.95,1.33) |
||||||||||||
| 2 |
rs17300741 |
11:64331462 |
A/G |
1.08 |
0.402 |
0.446 |
1.04 |
0.793 |
0.173 |
1.10 |
0.469 |
0.254 |
1.07 |
0.396 |
0.388 |
| (0.90,1.29) |
(0.78,1.38) |
(0.86,1.40) |
(0.92,1.24) |
||||||||||||
| 2 |
rs2078267 |
11:64334114 |
C/T |
1.00 |
0.999 |
0.499 |
1.84 |
0.012 |
0.804 |
1.51 |
0.022 |
0.591 |
1.08 |
0.370 |
0.169 |
| (0.84,1.20) |
(1.14,2.95) |
(1.06,2.14) |
(0.91,1.28) |
||||||||||||
| 3 |
rs3825018 |
11:64358809 |
G/A |
1.24 |
0.028 |
0.660 |
1.33 |
0.020 |
0.568 |
1.34 |
0.008 |
0.767 |
1.27 |
0.002 |
0.822 |
| (1.02,1.50) |
(1.05,1.69) |
(1.08,1.66) |
(1.10,1.48) |
||||||||||||
| 3 |
rs475688 |
11:64364291 |
T/C |
1.31 |
0.011 |
0.360 |
0.95 |
0.683 |
0.216 |
1.03 |
0.768 |
0.096 |
1.13 |
0.109 |
0.093 |
| (1.06,1.60) |
(0.76,1.20) |
(0.84,1.27) |
(0.97,1.32) |
||||||||||||
| 3 |
rs7932775 |
11:64367862 |
C/T |
1.32 |
0.017 |
0.923 |
1.21 |
0.095 |
0.256 |
1.23 |
0.051 |
0.412 |
1.26 |
0.004 |
0.550 |
| (1.05,1.66) |
(0.97,1.51) |
(1.00,1.51) |
(1.08,1.48) |
||||||||||||
| 3 |
rs476037 |
11:64369540 |
A/G |
1.05 |
0.770 |
0.874 |
1.25 |
0.480 |
0.014 |
1.19 |
0.461 |
0.036 |
1.08 |
0.423 |
0.070 |
| (0.78,1.40] |
(0.67,2.34) |
(0.75,1.89) |
(0.89,1.31) |
||||||||||||
| 3 |
rs478607 |
11:64478063 |
G/A |
1.33 |
0.020 |
0.371 |
1.04 |
0.785 |
0.148 |
1.13 |
0.337 |
0.109 |
1.19 |
0.056 |
0.167 |
| (1.05,1.70) |
(0.79,1.36) |
(0.88,1.44) |
(1.00,1.43) |
||||||||||||
| 4 |
rs12289836 |
11:65436888 |
A/G |
0.87 |
0.156 |
0.435 |
0.89 |
0.327 |
0.717 |
0.91 |
0.423 |
0.791 |
0.88 |
0.085 |
0.863 |
| (0.72,1.05) |
(0.70,1.13) |
(0.73,1.14) |
(0.76,1.02) |
||||||||||||
| 4 | rs642803 | 11:65560620 | T/C | 0.97 |
0.728 | 0.267 | 0.95 |
0.662 | 0.862 | 1.00 |
0.982 | 0.726 | 0.96 |
0.586 | 0.818 |
| (0.81,1.16) | (0.76,1.19) | (0.81,1.23) | (0.84,1.11) | ||||||||||||
aLD block as shown in Additional file 2: Figure S1 and S2, block 1: upstream, block 2: SLC22A11, block 3: SLC22A12, block 4: downstream. bBase position is according to Genome Reference Consortium human genome build 37 (GRCh37). cEffect/Other, effect allele and other allele, all odds ratios (ORs) are calculated relevant to the effect allele defined as the allele in-phase with rs3825018 G allele according to 1,000 genomes linkage disequilibrium data. dCombining EP(L) and NZ European Caucasian sample sets. eCombining the EP(H), WP and EP/WP sample sets. fCombining the Eastern Polynesian EP high (EP(H)), EP low (EP(L)), Western Polynesian (WP) and EP/WP sample sets. gCombining the EP(H), EP(L), WP, EP/WP and NZ European Caucasian sample sets. hOR: inverse-variance weighted analysis OR (adjusted for sex); P: inverse-variance weighted analysis P-value; Het P: heterogeneity P-value, inverse-variance weighted analyses were reanalyzed using a random-effects model if the Het P was <0.05.