Table 3.
Inverse-variance weighted analysis of block- 1 to -3 haplotypes
| |
European Caucasian and low ancestry Polynesian
b
|
High ancestry Polynesian
c
|
Polynesian
d
|
All ancestries
e
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hap a |
OR
f
|
P f | Het P f |
OR
f
|
P f | Het P f |
OR
f
|
P f | Het P f |
OR
f
|
P f | Het P f |
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | |||||||||
| Block 1 (rs475414|rs17299124) | ||||||||||||
| C|C |
0.94 |
0.501 |
0.795 |
0.89 |
0.305 |
0.884 |
0.91 |
0.349 |
0.936 |
0.92 |
0.242 |
0.978 |
| (0.78,1.13) |
(0.71,1.11) |
(0.74,1.11) |
(0.80,1.06) |
|||||||||
| T|A |
1.07 |
0.549 |
0.379 |
0.28 |
6.0 × 10,4 |
0.512 |
0.50 |
0.006 |
0.120 |
0.56 |
0.103 |
0.007 |
| (0.86,1.32) |
(0.14,0.58) |
(0.31,0.82) |
(0.28,1.12) |
|||||||||
| T|C |
1.02 |
0.848 |
0.584 |
1.30 |
0.022 |
0.914 |
1.29 |
0.019 |
0.965 |
1.14 |
0.093 |
0.572 |
| (0.83,1.25) |
(1.04,1.63) |
(1.04,1.56) |
(0.98,1.33) |
|||||||||
| Block 2 (rs693591|rs17300741|rs2078267) | ||||||||||||
| C|A|C |
0.97 |
0.800 |
0.726 |
1.24 |
0.070 |
0.128 |
1.20 |
0.083 |
0.219 |
1.10 |
0.253 |
0.179 |
| (0.76,1.24) |
(0.98,1.56) |
(0.98,1.49) |
(0.93,1.30) |
|||||||||
| G|A|C |
1.08 |
0.468 |
0.842 |
0.78 |
0.037 |
0.446 |
0.83 |
0.083 |
0.368 |
0.94 |
0.440 |
0.204 |
| (0.88,1.31) |
(0.61,0.99) |
(0.67,1.03) |
(0.81,1.10) |
|||||||||
| G|G|C |
, |
, |
, |
1.35 |
0.093 |
0.369 |
1.31 |
0.113 |
0.509 |
, |
, |
, |
| (0.95,1.91) |
(0.94,1.83) |
|||||||||||
| G|G|T |
0.97 |
0.706 |
0.682 |
0.57 |
0.022 |
0.797 |
0.69 |
0.042 |
0.600 |
0.91 |
0.252 |
0.316 |
| (0.81,1.15) |
(0.35,0.92) |
(0.49,0.99) |
(0.77,1.07) |
|||||||||
| Block 3 (rs3825018|rs475688|rs7932775|rs476037|rs478607) | ||||||||||||
| A|C|T|G|A |
0.82 |
0.040 |
0.953 |
0.76 |
0.035 |
0.272 |
0.77 |
0.024 |
0.451 |
0.80 |
0.004 |
0.594 |
| (0.67,0.99) |
(0.59,0.98) |
(0.62,0.97) |
(0.68,0.93) |
|||||||||
| G|C|C|G|A |
1.06 |
0.816 |
0.425 |
1.31g |
0.105 |
0.969 |
1.23g |
0.183 |
0.543 |
1.22h |
0.142 |
0.746 |
| (0.66,1.69) |
(0.95,1.81) |
(0.91,1.67) |
(0.94,1.60) |
|||||||||
| G|C|C|G|G |
, |
, |
, |
1.33 |
0.116 |
0.702 |
1.29 |
0.151 |
0.752 |
, |
, |
, |
| (0.93,1.90) |
(0.91,1.81) |
|||||||||||
| G|T|C|G|A |
, |
, |
, |
0.93 |
0.730 |
0.905 |
, |
, |
, |
, |
, |
, |
| (0.63,1.39) | ||||||||||||
| G|T|C|G|G |
1.41 |
0.007 |
0.248 |
0.63 |
0.028 |
0.821 |
0.86 |
0.690 |
0.028 |
1.01 |
0.984 |
0.014 |
| (1.10,1.82) |
(0.41,0.95) |
(0.41,1.80) |
(0.61,1.66) |
|||||||||
| G|T|T|A|A | 1.01 |
0.947 | 0.731 | 1.19 |
0.573 | 0.029 | 1.07 |
0.590 | 0.062 | 1.06 |
0.579 | 0.118 |
| (0.87,1.29) | ||||||||||||
| (0.75,1.36) | (0.66,2.14) | (0.84,1.36) | ||||||||||
aBlock 1 (rs475414|rs17299124), block 2 (rs693591|rs17300741|rs2078267), block 3. (rs3825018|rs475688|rs7932775|rs476037|rs478607) excluding frequency <0.01. bCombining the Eastern Polynesian (EP) low (EP(L)) and NZ European Caucasian sample sets. cCombining the EP high (EP(H)), Western Polynesian (WP) and EP/WP sample sets. dCombining the EP(H), EP(L), WP, and EP/WP sample sets. eCombining the EP(H), EP(L), WP, EP/WP and NZ European Caucasian sample sets. fOR: Inverse-variance weighted analysis odds ratio (adjusted for sex); P: inverse-variance weighted analysis P-value; Het P: heterogeneity P-value, inverse-variance weighted analyses were reanalyzed using a random-effects model if the Het P was <0.05. gEP/WP cohort was excluded from this meta-analysis owing to no female controls having the G|C|C|G|A haplotype.