Table 2.
Baseline characteristics in normal and uremic rats
| Characteristic | Group 1, Sham- C (n = 5) | Group 2, CKD (n = 7) | Group 3, CKD-Pc (n = 5) | Group 4, CKD-E (n = 5) |
|---|---|---|---|---|
| Weight, grams | 346±18 (340, 295–405) | 319±7.7 (325, 290–340) | 325±25 (355, 250–380) | 356±13 (365, 320–390) |
| Systolic blood pressure, mm Hg | 133±0.9 (133, 129–135) | 133±0.6 (133, 130–135) | 131±0.9 (132, 128–133) | 132±0.4 (132, 131–134) |
| Creatinine, mg/dL | 0.38±0.04 (0.4, 0.3–0.5) | 0.41±0.03 (0.4, 0.3–0.5) | 0.38±0.04 (0.4, 0.3–0.5) | 0.38±0.04 (0.4, 0.3–0.5) |
| Calcium, mg/dL | 8.4±0.5 (8.3, 7.1–10.0) | 8.6±0.2 (8.4, 8.0–9.8) | 8.5±0.3 (8.6, 7.6–9.1) | 8.8±0.2 (9.0, 8.1–9.2) |
| Phosphorus, mg/dL | 4.4±0.3 (4.7, 3.3–5.2) | 5.4±0.4 (5.6, 3.4–6.8) | 4.8±0.2 (4.6, 4.2–5.4) | 5.6±0.4 (5.5, 4.8–6.9) |
| Proteinuria, mg/24 hours | 2.0±0.3 (1.7, 1.3–2.9) | 1.5±0.1 (1.4, 1.2–2.0) | 1.9±0.2 (1.8, 1.3–2.6) | 0.9±0.1 (0.9, 0.6–1.2) |
Rats were divided into 4 groups (groups 1–4) and studied for 8 weeks. Sham (control, C), untreated 5/6 nephrectomy (chronic kidney disease (CKD)) received vehicle, CKD-Pc (paricalcitol), CKD-E (enalapril). Results are expressed as mean ± standard error of the mean (median, range), n = number of animals in each group.