Table 3.
Effects of treatment on blood pressure and chemical parameters in rats with renal ablation
| Examined Parameter | Group 1, Sham- C (n = 5) | Group 2, CKD (n = 7) | Group 3, CKD-Pc (n = 5) | Group 4, CKD-E (n = 5) |
|---|---|---|---|---|
| Systolic blood pressure, mm Hg | 132±1.9 (133, 130–135) | 204±18* (207, 168–222) | 156±8.0 (156, 143–164) | 143±9.5** (144, 133–157) |
| Plasma creatinine, mg/dL | 0.58±0.04 (0.6, 0.5–0.7) | 1.33±0.25c (1.0, 0.9–2.8) | 0.76±0.05 (0.8, 0.6–0.9) | 0.76±0.03 (0.8, 0.7–0.8) |
| Proteinuria, mg/24 hours | 4.2±1.7 (5.5, 0.1–8.7) | 62±9.0a (63, 30–89) | 17±13 (4.8, 2.3–68) | 11±4.8 (7.1, 4.8–30) |
| Calcium, mg/dL | 7.3±0.1 (7.4, 7.0–7.7) | 8.5±0.3 (8.3, 7.8–9.7) | 9.9±0.8b (10.1, 7.3–11.9) | 7.7±0.3 (7.7, 6.7–8.3) |
| Phosphorus, mg/dL | 6.7±0.2 (6.8, 6.0–7.3) | 7.3±0.7 (7.6, 3.5–9.6) | 6.5±0.8 (5.8, 4.8–8.7) | 6.3±0.8 (6.2, 3.9–8.7) |
Blood pressure, plasma creatinine, calcium, phosphorus, and proteinuria after 8 weeks of treatment with paricalcitol (Pc) or enalapril (E) compared with untreated 5/6 nephrectomy (chronic kidney disease (CKD)) and sham control animals (C). Results are expressed as mean ± standard error of the mean (median, range); n = number of animals in each group.
a P < 0.05 vs. C and Pc; b P < 0.05 vs. C; c P < 0.001 vs. C.
*P < 0.001 vs. C; **P < 0.05 vs. CKD.