Table 6.
Change in clinical and functional status between baseline and one year by APR levels among biologic-naïve patients
| |
Neither APR elevated |
APR levels discordant |
Both APR elevated |
P
value |
|---|---|---|---|---|
| n = 1,012 | n = 487 | n = 324 | ||
| mHAQ |
0.00 ± 0.29 |
-0.06 ± 0.35 |
-0.14 ± 0.41 |
<0.0001 |
| CDAI |
-2.91 ± 10.92 |
-4.93 ± 12.35 |
-8.16 ± 13.53 |
<0.0001 |
| Tender joints |
-0.91 ± 5.54 |
-1.69 ± 5.88 |
-2.82 ± 6.64 |
<0.0001 |
| Swollen joints |
-1.28 ± 5.11 |
-1.85 ± 5.60 |
-2.81 ± 5.78 |
<0.0001 |
| Patient global assessment |
-2.14 ± 26.41 |
-6.00 ± 27.96 |
-10.58 ± 30.18 |
<0.0001 |
| MD global assessment | -5.23 ± 16.46 | -7.62 ± 19.49 | -14.62 ± 22.91 | <0.0001 |
APR, acute phase reactant; mHAQ, modified Health Assessment Questionnaire; CDAI, Clinical Disease Activity Index.