Table 3.
Variables associated with ischemic arterial events in systemic sclerosis patients after age adjustment.
| Any event (n = 20) | IHD (n = 13) | IPVD (n = 9) | ||||
|---|---|---|---|---|---|---|
| Odds ratio (95% CI) | P value | Odds ratio (95% CI) | P value | Odds ratio (95% CI) | P value | |
| Age | 1.10 (1.05-1.17) | <0.0001 | 1.06 (1.01-1.13) | 0.02 | 1.13 (1.05-1.26) | 0.0005 |
| Associations after adjustment for age | ||||||
| Kidney disease | 8.8 (1.5-55.8) | 0.01 | 6.6 (1.12-36.15) | 0.04 | ND | 0.3 |
| Skin score | 1.13 (1.03-1.24) | 0.008 | 1.07 (0.97-1.18) | 0.1 | 1.16 (1.02-1.32) | 0.02 |
| Disease severity | 1.29 (1.05-1.62) | 0.02 | 1.11 (0.88-1.39) | 0.4 | 1.15 (0.85-1.55) | 0.3 |
| ACA+ | 3.61 (1.21-11.3) | 0.02 | 1.9 (0.55-6.45) | 0.2 | 6.8 (1.37-45.3) | 0.02 |
| ATA+ | 0.18 (0.01-1.01) | 0.05 | 0.00003 (0-0.6) | 0.01 | 0.83 (0.04-5.67) | 0.9 |
| VCAM-1 | 5.30 (0.51-62.1) | 0.2 | 27.3 (2.52-427. 4) | 0.005 | 0.37 (0.02-5.46) | 0.2 |
| VEGF | 0.68 (0.24-1.84) | 0.4 | 0.29 (0.09-0.93) | 0.03 | 0.52 (0.12-2.33) | 0.4 |
| eGFR | 0.26 (0.10-0.62) | 0.003 | 0.32 (0.12-0.81) | 0.02 | 0.57 (0.15-3.65) | 0.5 |
IHD, ischemic heart disease; IPVD, ischemic peripheral vascular disease; CI, confidence interval; ACA, anticentromere antibody; +, positivity; ATA, antitopoisomerase 1 antibody; VCAM-1, vascular cell adhesion molecule 1; VEGF, vascular endothelial growth factor; eGFR, estimated glomerular filtration rate, based on cystatin C measurements.