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Two-dimensional gel electrophoresis of serum proteins of healthy subjects receiving 4 g of acetaminophen daily for 7 days. (A) Native serum of healthy volunteers or (B) after immunodepletion of high abundant proteins, such as serum albumin (1) and immunoglobulin G (4). An improved resolution of apolipoprotein H (2) and apolipoprotein E (3) and haptoglobin (5) was achieved in depleted sera.
