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. 2014 Feb 27;6(2):18. doi: 10.1186/gm535

Table 2.

Mutated genes and loci information for EGFR / KRAS -negative lung adenocarcinomas from our cohort, the expansion cohort, and The Cancer Genome Atlas cohort

Gene Mutation frequency in our set (N = 16) Mutation frequency in expansion set (N = 40) Mutation frequency in TCGA set (N = 14) Total (N) AA substitution COSMIC v.65 Number of damage algorithms
TP53
 -
 6 of 40
 2 of 14
 8 of 70
 K93R
 O
 4 of 4
122_122del
 O
 n/a
Y124C
 O
 4 of 4
C203F
 O
 4 of 4
G206S
 O
 4 of 4
R209W
 O
 4 of 4
E219*
 O
 2 of 4
G295A
 O
 4 of 4
SETD2
 1 of 16
 2 of 40
 1 of 14
 4 of 70
 R839*
 -
 1 of 2
V1576F
 -
 3 of 3
Q1981*
 -
 2 of 2
K2067*
 -
 0 of 1
CSMD3
 1 of 16
 1 of 40
 2 of 14
 4 of 70
 P667S
 O
 3 of 4
M1440I
 -
 3 of 4
K1928N
 -
 3 of 4
Y2028C
 -
 3 of 4
PTPRC
 2 of 16
 1 of 40
 -
 3 of 70
 Y444N
 O
 3 of 4
T453M
 -
 3 of 4
T1176M
 -
 4 of 4
SYNE2
 1 of 16
 2 of 40
 -
 3 of 70
 2579_2580del
 -
 n/a
E3880*
 -
 n/a
E3903K
 O
 3 of 4
GRIN2A
 -
 3 of 40
 -
 3 of 70
 L307Q
 -
 3 of 4
N886S
 O
 0 of 4
T1069M
 O
 3 of 4
CDH10
 -
 2 of 40
 1 of 14
 3 of 70
 E171K
 O
 4 of 4
D315H
 O
 1 of 4
R472C
 O
 4 of 4
ERBB2
 -
 -
 3 of 14
 3 of 70
 E740delinsEAYVM (2)
 -
 n/a
G746delinsVC
 O
 n/a
SMAD4
 -
 -
 3 of 14
 3 of 70
 S242*
 -
 1 of 2
R361S
 O
 4 of 4
D493N
 O
 3 of 4
CDC27
 2 of 16
 -
 -
 2 of 70
 I235T
 -
 4 of 4
A273G
 O
 3 of 4
GABRG1
 2 of 16
 -
 -
 2 of 70
 D43N
 -
 2 of 4
T318S
 -
 3 of 4
YTHDF1
 2 of 16
 -
 -
 2 of 70
 I492V (2)
 -
 4 of 4
PCDHB14
 2 of 16
 -
 -
 2 of 70
 Y670S (2)
 -
 2 of 3
MECP2
 1 of 16
 -
 1 of 14
 2 of 70
 R168L
 -
 2 of 3
G273V
 O
 3 of 3
NRAS
 -
 2 of 40
 -
 2 of 70
 Q61H
 O
 2 of 4
Q61K
 O
 3 of 4
MET
 -
 -
 2 of 14
 2 of 70
 Y1021*
 -
 2 of 2
1027_1028del
 -
 NA
EPHA2
 -
 2 of 40
 -
 2 of 70
 P147L
 O
 4 of 4
P278S
 O
 2 of 4
CHD2
 -
 2 of 40
 -
 2 of 70
 S391fs
 -
 n/a
splicing(c.5153)
 O
 n/a
MST1
 -
 -
 2 of 14
 2 of 70
 406_407del
 -
 n/a
R535G
 -
 3 of 4
ERBB4
 1 of 16
 -
 -
 1 of 70
 V840I
 O
 4 of 4
PIK3CA
 1 of 16
 -
 -
 1 of 70
 G118D
 O
 2 of 3
AKT2
 1 of 16
 -
 -
 1 of 70
 D153Y
 -
 4 of 4
TSC1
 1 of 16
 -
 -
 1 of 70
 Q793*
 -
 2 of 2
CTNNB1
 1 of 16
 -
 -
 1 of 70
 S37C
 O
 4 of 4
TGFBR2
 1 of 16
 -
 -
 1 of 70
 R504W
 O
 4 of 4
PBRM1
 1 of 16
 -
 -
 1 of 70
 E830*
 -
 2 of 2
MBD2
 1 of 16
 -
 -
 1 of 70
 E373K
 -
 4 of 4
CHEK2
 1 of 16
 -
 -
 1 of 70
 R191G
 -
 3 of 4
PARP4
 1 of 16
 -
 -
 1 of 70
 I1039T
 O
 4 of 4
CUL3
 1 of 16
 -
 -
 1 of 70
 Q516*
 -
 2 of 2
SOD2
 1 of 16
 -
 -
 1 of 70
 K194E
 -
 3 of 4
GABRD
 1 of 16
 -
 -
 1 of 70
 D174E
 -
 4 of 4
NDRG1
 1 of 16
 -
 -
 1 of 70
 L257fs
 -
 n/a
TFG
 1 of 16
 -
 -
 1 of 70
 E240*
 -
 1 of 1
SYK
 1 of 16
 -
 -
 1 of 70
 A400S
 -
 4 of 4
ASPSCR1
 1 of 16
 -
 -
 1 of 70
 L252Q
 -
 3 of 3
PCDHB15 1 of 16 - - 1 of 70 Y670S - 3 of 3

COSMIC, Catalogue of Somatic Mutations in Cancer; n/a, not available; TCGA, The Cancer Genome Atlas.