Table 1.

Hallmarks of cancer progression and roles played by the hemostatic system

Hallmarks of cancer progression	Platelets	Coagulation	Fibrinolysis
Genetic instability	Indirect evidence only [86]	No	No
Tumor-promoting inflammation	No	Yes [51]	No
Sustained proliferative signaling	Yes [14,15,25]	Yes [51]	Yes [76,78]
Evasion of anti-growth signaling	Yes [14]	No	No
Prevention of apoptosis	Yes [14]	Yes [51,86]	Yes [76-78]
Replicative immortality	No	No	No
Deregulated metabolism	No	No	No
Immune system evasion	Yes [12]	No	No
Angiogenesis	Yes [15,17,23,24]	Yes [51,68,70,72]	Yes [79]
Tissue invasion and metastasis	Yes [6,14,15,18,25,32]	Yes [51,70]	Yes [76,77]