Table 1.
Hallmarks of cancer progression | Platelets | Coagulation | Fibrinolysis |
---|---|---|---|
Genetic instability | Indirect evidence only [86] | No | No |
Tumor-promoting inflammation | No | Yes [51] | No |
Sustained proliferative signaling | Yes [14,15,25] | Yes [51] | Yes [76,78] |
Evasion of anti-growth signaling | Yes [14] | No | No |
Prevention of apoptosis | Yes [14] | Yes [51,86] | Yes [76-78] |
Replicative immortality | No | No | No |
Deregulated metabolism | No | No | No |
Immune system evasion | Yes [12] | No | No |
Angiogenesis | Yes [15,17,23,24] | Yes [51,68,70,72] | Yes [79] |
Tissue invasion and metastasis | Yes [6,14,15,18,25,32] | Yes [51,70] | Yes [76,77] |