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. 2013 Nov 18;15(6):R191. doi: 10.1186/ar4381

Figure 1.

Figure 1

Expression of SOCS1 in osteoarthritic cartilage. Cartilage samples from four patients with femoral neck fracture and six with knee OA were immune-stained, as described in Methods. No to minimal SOCS1 expression was observed in healthy cartilage, whereas the intensity of SOCS1 expression and the number of SOCS1-positive cells increased in OA cartilage, especially in areas of severe cartilage damage (A, original magnification × 200). SOCS1 was localized in the cytoplasm and nucleus (B, original magnification × 200). The percentage of SOCS1-expressing chondrocytes was significantly higher in the severe OA lesions as compared with mild OA and healthy cartilage (C; P < 0.01). Data were expressed as the means ± SEM. *Corrected P < 0.05 by Mann–Whitney test with Bonferroni correction.