Table 2.
Frequency of the minor allele of P2RX7 A1405 G allele in pSS patients and controls
| Cohort | Group | Number | A1405G MAFa | Odds ratio (95% CI) | P-value |
|---|---|---|---|---|---|
| Cohort 1 | Controls | 136 | 0.15 | 1 | |
| All pSS | 114 | 0.20 | 1.46 (0.91, 2.34) | 0.12 | |
| Seronegative pSS | 19 | 0.07 | 0.44 (0.13,1.52) | 0.22 | |
| Seropositive pSS | 95 | 0.23 | 1.78 (1.09, 2.92) | 0.02 | |
| Cohort 2 | Controls | 534 | 0.15 | 1 | |
| All pSS | 281 | 0.17 | 1.07 (0.79, 1.45)b | 0.64 | |
| Seronegative pSS | 82 | 0.21 | 1.35 (0.87, 2.10) b | 0.18 | |
| Seropositive pSS | 199 | 0.16 | 0.96 (0.68, 1.36) b | 0.83 |
aMAF, minor allele frequency; bprincipal components adjusted analysis; pSS, primary Sjögren's syndrome.