Table 4.
Association between mammographic density categorized into quartiles and local and locoregional recurrence
| Local recurrence | Locoregional recurrence | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Model 1a | 0.008 | 0.012 | ||||
| PD, 1st quartileb | 1.00 (Ref.) | 1.00 (Ref.) | ||||
| PD, 2nd quartilec | 1.72 | 0.78-3.78 | 1.43 | 0.79-2.60 | ||
| PD, 3rd quartiled | 1.91 | 0.86-4.24 | 1.34 | 0.72-2.50 | ||
| PD, 4th quartilee | 3.14 | 1.38-7.16 | 2.36 | 1.27-4.39 | ||
| Model 2f | 0.017 | 0.035 | ||||
| PD, 1st quartileb | 1.00 (Ref.) | 1.00 (Ref.) | ||||
| PD, 2nd quartilec | 1.80 | 0.80-4.05 | 1.38 | 0.75-2.53 | ||
| PD, 3rd quartiled | 1.78 | 0.77-4.11 | 1.29 | 0.68-2.45 | ||
| PD, 4th quartilee | 3.03 | 1.28-7.17 | 2.10 | 1.11-3.97 | ||
aAdjusted for age, body mass index (BMI), and hormone replacement therapy (HRT) use;
bpercentage density (PD) <6.46, n = 443;
c6.46 ≤ PD <13.66, n = 444;
dPD 13.66 ≤ PD <25.07, n = 444;
ePD ≥25.07, n = 443;
fadjusted for age, BMI, HRT use, mode of detection, tumor size, lymph node metastasis, estrogen receptor status, progesterone receptor status, and grade. CI, confidence interval; HR, hazard ratio; Ref., reference value.