Table 5.
Association between percentage density (≥25% compared with <25%) and local recurrence stratified on surgical method
| Breast-conserving surgery | Mastectomy | |||||
|---|---|---|---|---|---|---|
| Local recurrence | 41 events Time at risk = 5,959 years |
21 events Time at risk = 3,734 years |
||||
| HR | CI | P value | HR | CI | P value | |
| Model 1a | 1.53 | 0.70-3.31 | 0.286 | 3.44 | 1.26-9.38 | 0.016 |
| Model 2b | 1.48 | 0.67-3.25 | 0.334 | 2.93 | 1.03-8.39 | 0.045 |
| Locoregional recurrence | 61 events Time at risk = 5,924 years |
42 events Time at risk = 3,690 years |
||||
| HR | CI | P value | HR | CI | P value | |
| Model 1a | 1.45 | 0.78-2.70 | 0.242 | 2.69 | 1.34-5.43 | 0.006 |
| Model 2b | 1.57 | 0.83-2.97 | 0.166 | 2.16 | 1.02-4.54 | 0.044 |
aAdjusted for age, body mass index (BMI), and hormone replacement therapy (HRT) use.
bAdjusted for age, BMI, HRT use, mode of detection, tumor size, lymph node metastasis, estrogen receptor status, progesterone receptor status, and grade. CI, confidence interval; HR, hazard ratio.