Table 1.
Donor details |
Sample classification |
||||||||
---|---|---|---|---|---|---|---|---|---|
Ref. | Source | Age (y) | Level | Intact | cDNA | IL-16 IHC | CCL2 IHC | CCL7 IHC | CXCL8 IHC |
1 |
S |
42 |
L4/L5 |
No |
I |
4.0* |
4.0* |
4.2* |
4.0* |
2 |
S |
40 |
L5/S1 |
Yes |
I |
7.3* |
7.3* |
5.7* |
7.3* |
3 |
S |
25 |
L4/L5 |
Yes |
D |
4 |
4 |
4.7 |
4 |
4 |
S |
48 |
L4/L5 |
Yes |
NA |
4.0* |
4.0* |
5.7* |
4.0* |
5 |
S |
33 |
L5/S1 |
Yes |
D |
NA |
NA |
NA |
NA |
6 |
S |
NA |
NA |
NA |
NA |
6.0* |
6.0* |
7.0* |
6.0* |
7 |
S |
62 |
L4/L5 |
Yes |
NA |
7.5 |
7.5 |
7.3 |
7.5 |
8 |
S |
32 |
L5/S1 |
Yes |
N |
2.3 |
2.3 |
3 |
2.3 |
9 |
S |
26 |
L5/S1 |
Yes |
NA |
NA |
3.3 |
NA |
3.3 |
10 |
S |
53 |
L4/L5 |
No |
NA |
7.5* |
7.5* |
7.5* |
7.5* |
11 |
S |
40 |
L5/S1 |
Yes |
NA |
7.4 |
7.4 |
5.5 |
7.4 |
12 |
S |
66 |
L5/S1 |
NA |
NA |
5.7* |
5.7* |
5.5* |
5.7* |
13 |
S |
34 |
L4/L5 |
Yes |
NA |
6.2 |
6.2 |
7.5 |
6.2 |
14 |
S |
NA |
NA |
Yes |
D |
NA |
NA |
NA |
NA |
15 |
S |
45 |
L5/S1 |
Yes |
D |
NA |
NA |
NA |
NA |
16 |
S |
26 |
L4/L5 |
Yes |
I |
NA |
NA |
NA |
NA |
17 |
S |
23 |
L4/L5 |
Yes |
N |
NA |
NA |
NA |
NA |
18 |
S |
29 |
L4/L5 |
Yes |
I |
NA |
NA |
NA |
NA |
19 |
S |
35 |
L5/S1 |
No |
N |
NA |
NA |
NA |
NA |
20 |
S |
20 |
L4/L5 |
No |
I |
NA |
NA |
NA |
NA |
21 |
S |
39 |
L5/S1 |
No |
I |
NA |
NA |
NA |
NA |
22 |
PM |
45 |
L4/L5 |
Yes |
N |
1.8 |
1.8 |
2 |
1.8 |
23 |
PM |
45 |
L3/L4 |
Yes |
N |
3 |
3 |
2.5 |
3 |
24 |
PM |
45 |
L5/S1 |
Yes |
NA |
3.5 |
3.5 |
3.5 |
3.5 |
25 |
S |
48 |
L4/L5 |
No |
D |
9.5 |
9.5 |
6 |
9.5 |
26 |
S |
26 |
L5/S1 |
No |
D |
11 |
11 |
3.5 |
11 |
27 |
S |
33 |
L5/S1 |
Yes |
I |
8.5* |
8.5* |
6.5* |
8.5* |
28 |
PM |
NA |
L1/L2 |
Yes |
NA |
10 |
10 |
6 |
10 |
29 |
PM |
NA |
L4/L5 |
Yes |
NA |
8 |
8 |
6 |
8 |
30 |
PM |
NA |
L5/S1 |
Yes |
NA |
7 |
7 |
9 |
7 |
31 |
PM |
NA |
L3/L4 |
Yes |
NA |
8 |
8 |
7.3 |
8 |
32 |
PM |
NA |
L2/L3 |
Yes |
NA |
11 |
11 |
10.3 |
11 |
33 |
S |
42 |
L5/S1 |
Yes |
N |
NA |
NA |
NA |
NA |
34 |
S |
36 |
L5/S1 |
Yes |
D |
8 |
8 |
4 |
8 |
35 |
S |
41 |
L5/S1 |
Yes |
D |
7.5 |
NA |
7.5 |
NA |
36 |
S |
NA |
NA |
NA |
I |
6.0* |
6.0* |
4.7* |
6.0* |
37 |
S |
44 |
L5/S1 |
Yes |
I |
3.0* |
3.0* |
2.3* |
3.0* |
38 |
S |
52 |
L4/L5 |
Yes |
D |
10.5 |
10.5 |
7 |
10.5 |
39 |
S |
NA |
L4/L5 |
No |
I |
9.0* |
9.0* |
6.2* |
9.0* |
40 |
S |
38 |
L5/S1 |
No |
I |
5.8* |
5.8* |
5.2* |
5.8* |
41 |
S |
28 |
L4/L5 |
Yes |
D |
7.7 |
7.7 |
3.5 |
7.7 |
42 |
S |
43 |
L5/S1 |
No |
D |
NA |
NA |
NA |
NA |
43 |
S |
44 |
L5/S1 |
Yes |
D |
NA |
NA |
NA |
NA |
44 |
S |
28 |
L5/S1 |
No |
D |
NA |
NA |
NA |
NA |
45 |
S |
35 |
L5/S1 |
Yes |
D |
NA |
NA |
NA |
NA |
46 |
S |
43 |
L5/S1 |
No |
D |
NA |
NA |
NA |
NA |
47 |
S |
42 |
L5/S1 |
No |
D |
NA |
NA |
NA |
NA |
48 |
S |
62 |
L3/L4 |
Yes |
I |
NA |
NA |
NA |
NA |
49 |
S |
40 |
L3/L4 |
Yes |
D |
NA |
NA |
NA |
NA |
50 | S | 45 | L4/L5 | No | I | NA | NA | NA | NA |
S, surgical; PM, post-mortem; I, infiltrated; D, degenerate; N, non-degenerate, IHC, immunohistochemistry; CCL, C-X-C chemokine. Surgically obtained prolapsed tissue samples were considered to be from intact IVDs when no signs of annulus fibrosus or cartilaginous endplate rupture were evident (protrusion-type prolapse). Values given for IHC sample classification are average histologically determined grades of degeneration; *infiltrating immune cells were observed; NA, not applicable.