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. 2012 May 25;153(8):3747–3757. doi: 10.1210/en.2012-1138

Fig. 5.

Fig. 5.

Improvement of neurological outcomes at 48 h after MCAO requires treatment by with progesterone and is PR dependent. A, Reduction in infarct volume by progesterone. **, P < 0.01 as compared with control mice; ###, P < 0.001; ##, P < 0.01 as indicated. B, Infarct areas on successive brain sections of PR+/+ and PR−/− mice. ***, P < 0.001; *, P < 0.05 as compared with the corresponding sections of progesterone-treated mice. C, Scatter plot and Pearson's correlation analysis of infarct volume vs. rotarod performance (r = −0.70; P < 0.001; dotted lines delimit the 0.95 confidence interval). D, Effects of MCAO and progesterone treatment on the time mice remained on a rotarod. ***, P < 0.001 compared with preischemia performance; ###, P < 0.001 as indicated. Data represent means ± sem; n = 16 per group.