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. Author manuscript; available in PMC: 2014 Apr 8.
Published in final edited form as: Nat Neurosci. 2012 Dec 2;16(1):25–32. doi: 10.1038/nn.3277

Figure 2.

Figure 2

NMDAR channel physiology. NMDAR-mediated EPSCs were measured in GluN2A2B(CTR)/2B(CTR), GluN2B2A(CTR)/2A(CTR) and GluN2B+/ΔC mice, and in associated wild-type controls. Bar charts show NMDAR/AMPA receptor (AMPAR) ratios for evoked EPSCs recorded at postsynaptic holding potentials of −80 mV or +40 mV and the time constants of the decay of EPSCs evoked at +40 mV. Traces show examples of evoked EPSCs at both holding potentials. GluN2AΔC/ΔC data were published previously42. (a) Results from GluN2A2B(CTR)/2B(CTR) cells (n = 12, N = 3) compared with GluN2A+/+ cells (n = 13, N = 3). (b) Results from GluN2B2A(CTR)/2A(CTR) cells (n = 24, N = 5) compared with GluN2B+/+ cells (n = 28, N = 5). (c) Results from GluN2B+/ΔC cells (n = 21, N = 4) compared with GluN2B+/+ cells (n = 17, N = 5). n represents the number of slices that we used and N represents the number of mice. Error bars represent s.e.m.