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. Author manuscript; available in PMC: 2014 Apr 8.
Published in final edited form as: Nat Neurosci. 2012 Dec 2;16(1):25–32. doi: 10.1038/nn.3277

Figure 4.

Figure 4

Emotion/motivation and motor behavior. (a) GluN2A2B(CTR)/2B(CTR) mice (n = 21) showed normal anxiety behavior relative to GluN2A+/+ controls (n = 22) (t41 = −1.49, P > 0.1). (b) GluN2B2A(CTR)/2A(CTR) mice (n = 21) showed significantly less anxiety than GluN2B+/+ controls (n = 19) (U = 70.5, P < 0.001). (c) GluN2AΔC/ΔC mice (n = 11) showed significantly less anxiety than GluN2A+/+ controls (n = 19) (U = 44.5, P = 0.01). (d) GluN2B+/ΔC mice (n = 15) showed normal anxiety relative to GluN2B+/+ controls (n = 10) (t23 = 0.5, P > 0.6). (e–h) Motor activity measured as total distance travelled (cm) in the open field over a 5-min period. (e) GluN2A2B(CTR)/2B(CTR) mice (n = 13) showed significantly more motor activity than GluN2A+/+ controls (n = 14) (t25 = −2.5, P < 0.05). (f) GluN2B2A(CTR)/2A(CTR) mice (n = 21) showed normal motor activity relative to GluN2B+/+ controls (n = 19) (t29.9 = 0.18, P > 0.8). (g) GluN2AΔC/ΔC mice (n = 11) showed significantly more motor activity than GluN2A+/+ controls (n = 19) (t28 = −3, P < 0.01). (h) GluN2B+/ÄC mice (n = 15) showed significantly more motor activity than GluN2B+/+ controls (n = 10) (t23 = −3.5, P < 0.005). (i–l) Impulsivity measured as latency to first enter the inner zone of the open field (s). (i) GluN2A2B(CTR)/2B(CTR) mice (n = 13) showed significantly more impulsivity than GluN2A+/+ controls (n = 14) (U = 41, P < 0.05). (j) GluN2B2A(CTR)/2A(CTR) mice (n = 21) showed significantly more impulsivity than GluN2B+/+ controls (n = 19) (U = 95, P < 0.005). (k) GluN2AÄC/ÄC mice (n = 11) showed significantly more impulsivity than GluN2A+/+ controls (n = 19) (t28 = 2.4, P < 0.05). (l) GluN2B+/ÄC mice (n = 15) showed normal impulsivity relative to GluN2B+/+ controls (n = 10) (t23 = 1.4, P > 0.1). *P < 0.05. All data are mean±s.e.m.