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. Author manuscript; available in PMC: 2014 Apr 8.
Published in final edited form as: Nat Genet. 2008 Jul 20;40(8):963–970. doi: 10.1038/ng.188

Figure 5.

Figure 5

p53 is sufficient and necessary to induce dark skin. (a,b) Immunofluorescence for p53 in footpad sections; white lines mark the dermal-epidermal junction. (c,d) Whole footpads from adult animals; all results shown are representative of at least three animals for each genotype. (e,f) Expression of Kitl mRNA in P30 footpad epidermis relative to Gapdh mRNA (mean ± s.e.m.) in animals of the indicated genotypes (two-tail P values are Trp53QS/+ versus Trp53QS/+; Tg.K5Cre/+ P = 0.00016; Rps6+/+ vs. Rps6lox/+; Tg.K5Cre P = 5 × 10–7; Rps6lox/+; Tg.K5Cre vs. Rps6lox/+; Tg.K5Cre; Trp53KO/KO P = 3.2 × 10–7). Scale bars: a,b, 25 μm.