Table 1.
Reference | Sample size |
Clinical setting | NGAL assay | Biofluid | AUC-ROC | Diagnostic/prognostic outcome |
---|---|---|---|---|---|---|
Mishra 2005 (15) |
71 | Children after cardiac surgery | WB, ELISA | Urine Plasma |
0.99 0.91 |
Prediction of AKI |
Dent 2007 (36) | 120 | Children after cardiac surgery | Triage | Plasma | 0.96 | Prediction of AKI |
Bennett 2008 (6) |
196 | Children after cardiac surgery | ARCHITECT | Urine | 0.95 | Prediction of AKI |
Wagener 2006 (37) |
81 | Adults after cardiac surgery | WB | Urine | 0.74 (3 hours) 0.80 (18 hours) |
Prediction of AKI |
Perry 2010 (32) |
879 | Adults after cardiac surgery | Triage | Plasma | 0.64 (after surgery) 0.74 (on day 3) |
Prediction of AKI |
Haase-Fielitz 2009 (38) |
100 | Adults after cardiac surgery | Triage | Plasma | 0.80-0.89 | Prediction of AKI |
Koyner 2010 (39) |
123 | Adults after cardiac surgery | ELISA | Urine | 0.88 (6 hours) | Prediction of AKI |
Parikh 2011 (31) |
1219 | Adults after cardiac surgery | ARCHITECT Triage |
Urine Plasma |
0.67 0.70 |
Prediction of AKI |
Hirsch 2007 (50) |
91 | Children after contrast agent | ELISA | Urine Plasma |
0.92 0.91 |
Prediction of AKI |
Bachorzewska- Gajewska 2006 (51) |
35 | Adults after contrast agent | ELISA | Urine Plasma |
NA NA |
Prediction of AKI |
Wheeler 2008 (33) |
143 | Critically ill septic children | ELISA | Plasma | 0.68 | Prediction of AKI |
Zappitelli 2007 (45) |
140 | Critically ill children | ELISA | Urine | 0.78 | Prediction of AKI |
Cruz 2010 (46) | 301 | Critically ill adults | Triage | Plasma | 0.78 | Prediction of AKI |
De Geus 2011 (44) |
632 | Critically ill adults | Triage | Urine Plasma |
0.76-0.80 | Differentiation of sustained AKI from non-sustained AKI and no AKI |
Bagshaw 2010 (48) |
82 | Critically ill adults with established AKI septic vs non septic |
ARCHITECT Triage |
Urine Plasma |
0.77 | Prediction of AKI progression and RRT |
Singer 2011 (41) |
145 | Hospitalized adults with established AKI | ARCHITECT | Urine | 0.87 | Diagnosis of intrinsic AKI (versus prerenal AKI) |
Hall 2011(42) | 249 | Hospitalized adults with established AKI | ELISA | Urine | 0.75 (prediction model of conv. Parameter + biomarker) |
Prediction of worsening AKI or in- hospital death |
Koyner 2012 (34) TRIBE-AKI |
380 | Hospitalized adults with established AKI | ARCHITECT Triage |
Urine Plasma |
0.79 (adjusted) 0.83 (adjusted) |
Prediction of worsening AKI |
Nickolas 2012 (30) |
1635 | Adult patients admitted to ER | WB, ARCHITECT |
Urine | 0.81 | Diagnosis of intrinsic AKI (versus prerenal AKI, stable CKD or normal function) |
Nickolas 2008 (40) |
635 | Adult patients admitted to ER | WB | Urine | 0.95 | Diagnosis of intrinsic AKI (versus prerenal AKI, stable CKD or normal function) |
Chen 2012 (43) |
150 | Adult patients admitted to coronary care unit |
ELISA | Plasma Urine |
0.83 0.80 |
Prediction of AKI onset and 6-mo mortality |
Trachtman 2006 (35) |
34 | Children with D+HUS | ELISA | Urine Plasma |
NA NA |
Prediction of RRT |
Yilmaz 2009 (49) |
89 | Children with UTI without AKI | ELISA | Urine | 0.99 | Diagnosis of UTI in absence of AKI |