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. Author manuscript; available in PMC: 2014 Apr 8.
Published in final edited form as: Nat Protoc. 2012 Aug 9;7(9):1608–1617. doi: 10.1038/nprot.2012.083

Figure 1.

Figure 1

AP20187 treatment induces temporal liver–specific damage in AFC8 mice. (a) The structure of the AFC8 mouse model transgene construct. (b) Activation of the AFC8 model’s transgene with the dimerizer AP20187 induces apoptosis through Caspase 8 signaling. (c) AFC8 mice (4–6 weeks old) were injected with AP20187 at indicated doses in accordance with the protocols and guidelines approved by the UNC Institutional Animal Care and Use Committee (IACUC); ALT was measured in serum at 1 d after drug treatment. Two animals per group (n = 2); error bars show means ± s.d.