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. 2014 Feb 10;289(13):9254–9262. doi: 10.1074/jbc.M113.514166

FIGURE 4.

FIGURE 4.

Knockdown of RAGE suppressed cystogenesis in PC2R mice. A, morphological comparison of the kidneys in each group. Representative data are presented. B, differences in kidney weight/total body weight between PC2R mice in each group. The weight of both kidneys and total body weight of the mice were measured. Then, the kidney weight/total body weight was calculated. Normal, WT littermates (n = 7); PC2R + Con Ad, control adenovirus-injected PC2R mice (n = 9); PC2R + anti-RAGE Ad, anti-RAGE adenovirus-injected PC2R mice (n = 9). C, analysis of BUN and creatinine levels. Serum was harvested from blood, and the BUN and creatinine levels were measured. WT littermates (n = 5); control adenovirus-injected (BUN; n = 6, Cr; n = 8); anti-RAGE adenovirus-injected (n = 5). Data are mean ± S.D. (error bars). **, p < 0.001; *, p < 0.05; ns, nonsignificant.