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Identification of ADMA and SDMA formation via neutral loss in wild type (top panel) and M48F-PRMT1 (bottom panel) reactions for triply charged dimethylated peptides. Peaks of m/z [M+3H-DMG]3+ and [M+2H-DMA]2+ indicate that there are ADMA sites, whereas the [M+3H-DMC]3+ peak indicates that there are SDMA sites.
