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Positioning of Pin1-mediated prolyl isomerization in post-phosphorylational Runx2 activation cascade. Functional activation of Runx2 is tightly controlled by multiple post-translational modification cascades that occur in the following sequence: phosphorylation, prolyl isomerization, and acetylation. In these processes, Pin1 has a role as a molecular switch to determine the fate of Runx2 acetylation and further transactivation.
